Blood clotting in minimally altered whole blood
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چکیده
منابع مشابه
Blood clotting in minimally altered whole blood.
The sequences of events regulating thrombin generation during tissue factor-initiated clotting in whole blood at 37 degrees C in which the contact pathway was suppressed with corn trypsin inhibitor are studied using quantitative Western blotting of factor V, prothrombin, platelet factor 4, antithrombin III, and fibrinogen. In addition, fibrinopeptide A (FPA), thrombin-antithrombin III (TAT) com...
متن کاملBlood Clotting in Minimally Altered Whole Blood
The sequences of events regulating thrombin generation during tissue factor-initiated clotting in whole blood at 37°C in which the contact pathway was suppressed with corn trypsin inhibitor are studied using quantitative Western blotting of factor V, prothrombin, platelet factor 4, antithrombin Ill, and fibrinogen. In addition, fibrinopeptide A (FPA), thrombin-antithrombin 111 (TAT) complex for...
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Experimental hypercalcaemia was induced in rats by (1) transplantation of the solid Walker 256 tumour, and (2) intraperitoneal injections of calcium gluconate. Whole blood clotting was studied by means of thromboelastography and whole blood clotting times in polystyrene and glass test tubes. At serum calcium levels between 10.3 and 11.5 m-equiv/l a slight delay in clot formation was found which...
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The coagulation cascade is a complex biochemical network replete with regulatory reactions and cellular contributions. The behavior of the system cannot necessarily be predicted intuitively from the existing state-of-the-art biochemical knowledge of the individual reactions. Knowledge of the reaction kinetics of the components in this complex system has major implications for an understanding o...
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The serine proteases, cofactors and cell-receptor molecules that comprise the haemostatic mechanism are highly conserved modular proteins that have evolved to participate in biochemical reactions in blood coagulation, anticoagulation and fibrinolysis. Blood coagulation is initiated by exposure of tissue factor, which forms a complex with factor VIIa and factor X, which results in the generation...
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ژورنال
عنوان ژورنال: Blood
سال: 1996
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood.v88.9.3432.bloodjournal8893432